| 대한안과학회 학술대회 발표 연제 초록 |
| 망막 F-034 |
| 타목시펜 망막병증의 유병률과 위험 인자 |
1. 울산대학교 의과대학 서울아산병원 안과 2. 강원대학교 의학전문대학원 안과학교실 |
| 김현아1, 이수환2, 어규상1, 윤영희1 |
목적 : To estimate the prevalence of tamoxifen retinopathy and to investigate its risk factors. 방법 : A total of 251 female breast cancer patients who received tamoxifen for more than 24 months before their most recent fundus photography and optical coherence tomography (OCT) examinations. Tamoxifen retinopathy was diagnosed based on characteristic findings: foveal cavitation on OCT, or refractile crystalline deposits on both the fundus photograph and OCT results. Medical records of participants were reviewed, and patients who received other medications known to promote the development of crystalline retinopathy or who had severe structural deformations in the macula were excluded. 결과 : Of the 251 patients analyzed in this study, 30 (12.0%) developed tamoxifen retinopathy. Among them, 26 had foveal cavitations, 4 had refractile crystalline deposits, and 14 had both. No differences were found in the mean age at initiation of tamoxifen use, the mean follow-up duration, the duration of tamoxifen treatment, or the cumulative dose of tamoxifen. However, the body mass index (BMI) was significantly higher in tamoxifen retinopathy patients (24.4±3.3 kg/m2 vs. 23.0±3.2 kg/m2, P = 0.023), and they also had a higher presence of hyperlipidemia (33.3% vs. 14.0%, P = 0.015). 결론 : Based on our concomitant use of OCT and fundus photography for the diagnosis of tamoxifen retinopathy, it was evident that the prevalence of this condition is higher than previously reported. We also found that a higher BMI and the presence of hyperlipidemia were more frequent in patients who developed tamoxifen retinopathy. |