| 대한안과학회 학술대회 발표 연제 초록 |
| 포도막 F-004 |
| 조혈모세포이식 후 발생한 거대세포바이러스 망막염의 임상양상 및 예후인자 |
1. 가톨릭대학교 의과대학 서울성모병원 안과 2. 가톨릭대학교 의과대학 시과학연구소 |
| 김주영1, 박우경1, 김래영1, 김미리내1, 박영근1, 박영훈1,2 |
목적 : To evaluate the ophthalmic characteristics of cytomegalovirus (CMV) retinitis and identify the prognostic factors in patients with CMV viremia after hematopoietic stem cell transplantation (HSCT). 방법 : We conducted a retrospective review of patients who diagnosed with CMV retinitis after HSCT between April 1, 2010 and December 31, 2018. The main outcomes included the initial best-corrected visual acuity (BCVA), BCVA at the diagnosis of CMV retinitis, BCVA at the last visit, involved zone, peak CMV DNA levels in the peripheral blood and aqueous humor, time between HSCT and the diagnosis of CMV retinitis, time between the diagnosis of CMV viremia and the diagnosis of CMV retinitis, treatment duration for CMV retinitis, number of intravitreal injections, complications, recurrence, and survival. 결과 : In total, 4241 patients underwent HSCT, 1063 of whom developed CMV viremia. CMV retinitis was diagnosed in 67 patients (93 eyes), 64 (88 eyes) of whom were enrolled. The mean BCVA (logarithm of the minimum angle of resolution) before HSCT was 0.041 ± 0.076, while that at the time of retinitis diagnosis and last visit was 0.266 ± 0.534 and 0.308 ± 0.553, respectively. Multiple regression analysis revealed that the involved zone (P = 0.005), time between HSCT and the diagnosis of CMV retinitis (P = 0.011), and survival status (P = 0.007) were associated with the final visual outcomes. 결론 : Greater invasion of the central retinal zone and a longer interval between HSCT and the diagnosis of retinitis result in worse final visual outcomes in patients with CMV retinitis after HSCT. Moreover, visual outcomes may be worse in patients who die than in those who survive. Prompt diagnosis of CMV retinitis through periodic retinal examinations of patients with CMV viremia after HSCT can prevent fatal visual outcomes. |