| 본문 : A 53-year-old female patient visited the ophthalmology clinic with complaint of visual deterioration in both eyes. She had been undergone paclitaxel chemotherapy for breast cancer with multiple metastasis. Her ophthalmologic history included a baseline visual acuity 20/30 in each eye and normal ophthalmologic findings 2 years prior to visual deterioration. Vision was 20/50 in each eye, and fundus examination showed macular thickening in both eyes. Fluorescein angiography showed petalloid dye pooling at fovea, and optical coherence tomography showed intraretinal fluid cysts with macular thickening in each eye. She was diagnosed as paclitaxel-associated retinopathy. Although the exact mechanism is still under investigation, paclitaxel-associated retinopathy can occur as a form of cystoid macular edema, leading to visual deterioration. The most effective treatment for paclitaxel-associated retinopathy is changing regimen of chemotherapy: substitution of paclitaxel to other chemotherapy agents, if possible. Conservative treatment can be also considered such as oral dorzolamide therapy or intravitreal injections of various agents including anti-vascular endothelial growth factor, although the effect is limited. If a patient who undergoes paclitaxel chemotherapy complains of visual deterioration, further ophthalmologic evaluation would be recommended. |