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목적 : To investigate baseline features associated with visual and anatomical outcomes after three loading injection of aflibercept in the patients with macular edema (ME) secondary to branch retinal vein occlusion (BRVO) from a prospective, multicenter PLATON trial.
방법 : All patients received 3 loading injections of aflibercept followed by treat and extend regimen. Best corrected visual acuity (BCVA; Early Treatment Diabetic Retinopathy Study [ETDRS] letters), and central macular thickness (CMT) were measured at each visit. To analyze the efficacy of the loading dose, subfoveal choroidal thickness (SCT), submacular fluid, cystoid changes, photoreceptor continuity, quantity of hyperreflective foci (HRF), and vitreomacular interface abnormalities were evaluated at baseline. Correlations between baseline features and outcomes after the loading dose were analyzed.
결과 : In the univariate regression model, age, presence of DRIL, disruption of ELM, baseline BCVA, and CMT were significantly associated with BCVA gain, and SCT, presence of HRF, presence of DRIL, disruption of ELM and EZ, and baseline BCVA were significantly correlated with CMT reduction. In the multivariate regression model, younger age (p<0.001) and worse baseline BCVA (p<0.001) were associated with better BCVA gain, and thicker SCT (p=0.003) and worse baseline BCVA (p=0.004) were correlated with better CMT reduction.
결론 : Most eyes treated with three monthly injection of aflibercept experience substantial visual gain. Better baseline BCVA and older age limited visual improvement and thinner SCT limited anatomical improvement.
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