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목적 : To evaluate quantitative metrics of the retinal microvasculature for the progression of diabetic retinopathy (DR) using various spectral-domain optical coherence tomography angiography (SD-OCTA) image sizes.
방법 : Superficial capillary plexus (SCP) and deep capillary plexus (DCP) images were acquired using an SD-OCTA device. The scanning protocols included the 3×3 and 6×6 mm fields of view. Quantitative analysis of the foveal avascular zone (FAZ) area, vessel density (VD), skeletal density (SD), fractal dimension (FD), and lacunarity was performed. Correlation between DR severity and microvascular alterations were analyzed by a repeated-measures analysis of variance (ANOVA). The area under the receiver operating characteristic curve was estimated to assess the parameters to predict the presence of DR.
결과 : This study included 121 eyes (healthy control, 20 eyes; no DR, 17 eyes; mild non-proliferative DR (mild NPDR), 10 eyes; moderate NPDR, 21 eyes; severe NPDR, 28 eyes; proliferative DR (PDR), 25 eyes). From each scan size, VD, SD, FD, and lacunarity progressively decreased and FAZ area increased with worsening DR severity in both SCP and DCP. For detecting DR, VD showed better prediction in 3×3 mm scan images and other parameters showed similar prediction in both scan images.
결론 : Progression of DR severity can be monitored in detail through quantitative evaluation of microvascular alterations that combine different scan sizes and parameters.
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