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목적 : To investigate the clinical characteristics and electrophysiologic findings of the pericentral retinitis pigmentosa (RP) patients including sectorial RP, compared with typical type of RP in Korean population.
방법 : The patients with pericentral RP with sectorial RP were enrolled in this study. Totally, 10 pericentral RP patients were evaluated, and 23 typical RP patients were participated as a control group. Comprehensive ophthalmic examinations including best corrected visual acuity (BCVA, LogMAR), intraocular pressure, presence of nyctalopia, automated visual field (AVF), and spectral-domain optical coherence tomography (SD-OCT) were performed for all subjects. Moreover, all subjects underwent full-field electroretinogram (ffERG) and multifocal electroretinogram (mfERG) according to ISCEV Standards.
결과 : Mean BCVA was 0.65±0.53 in pericentral RP and 0.68±0.62 in typical RP patients, respectively. Seven pericentral RP patients didn’t experience nyctalopia. Pericentral and ring scotoma with various extent were observed in AVF. The pericentral RP patients with foveal sparing on SD-OCT scan were 80% (8/10), and 43% (10/23) in typical RP patients. The mean amplitude of dark-adapted 3 ERG and light-adapted 30Hz flicker was significantly increased in pericentral RP patients. The mean N1 and P1 amplitudes from mfERG in central retina were also significantly higher in pericentral RP patients.
결론 : In this study, pericentral RP patients showed relatively better visual acuity, less visual field constriction and nyctalopia symptom. Furthermore, they noted significant more spared of macular structure, increased amplitudes in ffERG and mfERG recordings, compared to typical type of RP. These findings suggested that pericentral RP presented better retinal function, and it might be a mild type of RP. The limitation of this study is lack of genetic basis.
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