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목적 : To investigate the roles of vascular dysregulation and instability in normal-tension glaucoma (NTG), we determined the serum levels of renin and angiotensin II.
방법 : Thirteen patients with NTG and age-matched 24 healthy controls were enrolled in this study. Blood samples from all subjects were assayed for renin and angiotensin II.
결과 : There were no significant differences in age, gender, visual acuity, intraocular pressure, refractive power, systemic and diastolic pressure between the NTG and control groups. The systemic levels of renin were significantly higher in the NTG group than in the control group (p = 0.037). However, the angiotensin II levels were not significantly different between the NTG and control groups (p = 0.281).
결론 : After excluding patients with cardiovascular diseases, serum renin levels were elevated in patients with NTG. The angiotensin II levels were not significantly different in NTG. Increased renin levels suggest that ischemia/inflammation may play a role in the pathogenesis of NTG.
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