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목적 : To characterize intereye differences in posterior segment parameters and determine their significance in normal tension glaucoma (NTG) patients with unilateral damage.
방법 : 65 subjects without damage and 43 patients with unilateral NTG were included. Coronally reconstructed optical coherence tomography images were analyzed to determine the deepest point of the eye (DPE), which we then calculated the distance (Disc-DPE distance), depth (Disc-DPE depth), angle (Disc-DPE angle) from the optic disc center to the DPE. Posterior pole shape was analyzed measuring the posterior pole-cross-sectional area (PP-CSA), horizontal width (PP-HW) and vertical width (PP-VW) of the posterior pole. These measurements and their intereye absolute difference (IAD) values were compared.
결과 : The posterior sclera measurements, including the Disc-DPE distance, Disc-DPE depth, and PP-CSA, were significantly different between the unilateral glaucoma eyes and contralateral healthy eyes (P=0.043, P=0.035, and P=0.049, respectively). By contrast, none of the intereye differences in optic nerve head parameters were significant in the unilateral glaucoma patients. In comparison to the IAD values, the baseline intraocular pressure (IOP) and PP-HW of the posterior segment showed significant differences between the healthy and the unilateral NTG patients (P=0.019 and P=0.036, respectively).
결론 : Compared to the fellow healthy eyes, glaucomatous eyes had larger and more steeply curved posterior poles, which represents a structural variation of the posterior sclera that might be associated with glaucomatous optic neuropathy.
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