| 발표일자: |
2019년 11월 1일(금)~3(일) |
| 발표번호: |
P(e-poster)-099 |
| 발표장소: |
B3 Parking Area
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| 연령 관련 황반 변성 환자에서 T 세포의 케모카인 수용체의 양상 |
| 가톨릭관동대학교 의과대학 안과학교실 (1) 건국대학교 의과대학 안과학교실 (2), 연세대학교 의과대학 안과학교실 (3), 카이스트 의과학대학원 (4) |
| 최영준 (1), 임대한 (2), 변석호 (3), 신의철 (4), 정혜원 (1) |
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목적 : To evaluate the expression of multiple chemokine receptors in peripheral blood T cells from patients with age-related macular degeneration (AMD).
방법 : Peripheral blood mononuclear cells and/or aqueous humor were obtained from 24 AMD patients and 24 age- and sex-matched healthy controls. Chemokine receptor expression on T cells from peripheral blood was determined by multicolor flow cytometry. The levels of chemokines and cytokines in the aqueous humor from 12 AMD patients and 6 healthy controls were assessed. Publicly accessible gene expression data (GSE29801: NCBI, Geo) were analyzed by a pathway analysis
결과 : AMD patients had increased expression of CCR4 in CD4 T cells and CRTh2 in CD8 T cells, and decreased expression of CXCR3 in CD4 T cells and CXCR3, CCR5, and CX3CR1 in CD8 T cells. MCP-1 levels were increased in the aqueous humor from AMD patients, but the levels of IL-4 and IL-22 were decreased significantly compared to controls. Gene expression data revealed decreased RNA expressions related to Th1 immune pathway in AMD patients, which is known to be associated with CXCR3 and CCR5 expression in T cells.
결론 : The chemokine receptor profiles of T cells are altered in AMD patients compared to healthy controls, suggestive of Th1 immune pathway suppression. Further evaluation is needed to clarify the implications of this alteration.
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