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목적 : To compare the efficacy as well as the safety of two maximum medical therapy combinations applied for lowering of intraocular pressure (IOP) in different primary open-angle glaucoma (POAG) age groups.
방법 : A retrospective, consecutive case series study, including 60 eyes of 60 subjects with POAG: 20 subjects aged 40-54, 21 aged 55-69, and 19 aged ≥ 70. All had been treated for at least 12 months with triple maximum medical therapy (TMT: dorzolamide/timolol, brimonidine, and latanoprost) to lower their IOP, which subsequently was changed to double maximum medical therapy (DMT: fixed drug combinations [FDCs] of tafluprost/timolol and brinzolamide/brimonidine). The rate of IOP change and adverse drug reactions (ADRs) were compared among the 3 age groups.
결과 : The mean IOP change after converting from TMT to DMT was -0.65±1.42 mmHg (-3.84±9.31%) in the overall patients, but it was not statistically significant (P=0.108). In the 40-54 and 55-69 years groups, the mean IOP change rate was +0.29±0.96 mmHg (+2.40±6.85%, P=0.087) and -0.50 ± 0.99 mmHg (-3.05±6.40%, P=0.084) respectively. In the ≥ 70 years group, the mean IOP change, interestingly, was -1.80±1.46 mmHg (-11.29±9.31%, P<0.001), and 9 (47.4%) of the 19 subjects showed additional IOP reduction ≥ 10% after converting from TMT to DMT.
결론 : In POAG patients, DMT was proved to be both effective and safe for lowering of IOP, especially in the ≥ 70 years group compared with the TMT protocol. These results suggest that for elderly patients, simplification of drug administration may improve adherence.
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