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목적 : The association between glaucoma and cancer development has not been investigated. Therefore, we compared the risk of cancer development between patients with glaucoma and those without.
방법 : We conducted a nationwide population-based cohort study using the Korean National Health Insurance Database. Individuals with diagnosis of glaucoma between 2007 and 2016 who also received a national general health screening in the same year were identified. Controls were 1:1 matched based on age and sex during the same period. We calculated the incidence rates and hazard ratios (HR) before and after adjusting for age, gender, diabetes, smoking history, and body mass index.
결과 : A total of 107,536 individuals with glaucoma and the same number of individuals without glaucoma were included. The incidence rates of overall cancer were 12.23 and 11.62 per 1,000 individuals in the glaucoma and control groups, respectively. The HR of overall cancer was significantly higher in the glaucoma group before (HR: 1.053, 95% confidence interval [CI]: 1.015-1.091) and after adjusting for confounding factors (adjusted HR: 1.049, 95% CI: 1.012-1.088) compared to that in the control group.
결론 : Our study revealed that individuals with glaucoma showed higher risk of overall cancer and higher risk of specific cancers than those without glaucoma. The risk of cancer was more prominent in female glaucoma patients and those younger than 65 years. Healthcare providers should carefully screen patients with glaucoma for the potential development of cancer.
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