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목적 : To compare the progression of localized retinal nerve fiber layer (RNFL) defects in red-free fundus photographs, en face structural images, and optical coherence tomography (OCT) angiography images.
방법 : We performed a retrospective, comparative study on 45 glaucomatous eyes showing RNFL defect widening in red-free fundus photography. The localized RNFL defect in red-free photograph was termed as red-free defect. The wedge-shaped hyporeflective area radiating from the optic nerve head in the OCT en face structural images and OCT angiography images were defined as en face defect and OCTA defect, respectively. The baseline and follow-up angular parameters, such as proximal/distal angular locations and angular width, of each red-free defects were compared with those of en face and OCTA defect.
결과 : When the baseline angular parameters were compared, there were no significant differences between red-free defect and en face defect, as well as between red-free defect and OCTA defect. In addition, the follow-up angular parameters showed no difference between red-free defect and en face defect. However, the OCTA defect showed significantly greater values compared to red-free defect and en face defect with respect to the distal angular location and angular width at follow-up visit.
결론 : Localized RNFL defects detected in red-free photographs showed high topographic correlation with defects detected in OCT en face structural images, and this correlation was also noted in eyes with progressive glaucoma. The OCT en face structural images may be an alternative to red-free fundus photography for identifying progressive localized RNFL defects in eyes with glaucoma.
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