| 발표일자: |
2019년 11월 1일(금)~3(일) |
| 발표번호: |
P(e-poster)-393 |
| 발표장소: |
B3 Parking Area
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| The Influence of Oral Statin Use on Outcome of Mitomycin-C Augmented Trabeculectomy. |
| Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand(1), Glaucoma Research Unit, Chulalongkorn University, Bangkok, Thailand(2)
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| Abhibol Inobhas, MD(2), Sunee Chansangpetch, MD, BPH(1,2), Anita Manassakorn, MD(1,2), Visanee Tantisevi, MD(1,2), Prin Rojanapongpun, MD(1,2) |
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Purpose : To examine the association between oral statin use and the outcomes of trabeculectomy due to the effect of statin on wound healing process is controversial, and little is known about its effect on trabeculectomy outcome.
Methods : The medical records of patients who underwent primary mitomycin-C augmented trabeculectomy and completed 2 years follow-up were reviewed. Pre and post-operation intraocular pressure (IOP), number of medications, number of subconjunctival 5-fluorouracil (5-FU) injections, and bleb needling procedures were compared between statin users and nonusers. Failure was defined as any eye that failed to get IOP lower than 20% from baseline, had IOP > 21mmHg, required further surgical intervention, developed hypotony, or had no light perception visual acuity.
Results : 46 eyes in statin users (39 patients) and 113 eyes in statin nonusers (96 patients) were eligible. There was no significant difference in the failure of trabeculectomy outcome at 24 months in both groups, 47.82% in statin users and 43.36% in nonusers (p=0.54). Additionally, there were no significant differences in the IOP (p=0.55) and the number of medications (p=0.36) at 24 months. The mean (SD) number of 5-FU injections in statin users and nonusers were 1.91 (2.21) and 1.33 (1.76), respectively. The linear mixed effect regression analysis showed a significantly higher number of 5-FU injections in statin users (ß 0.85, p=0.01). Furthermore, analyses of the success subgroup revealed that the number of 5-FU injections and bleb needling procedures in statin users were significantly higher than in nonusers (5-FU ß 1.18, p=0.006; needling ß 0.38, p=0.04).
Conclusion : This study demonstrates that oral statin use does not affect the trabeculectomy outcomes, but it increases the number of 5-FU injections and bleb needling procedures in the success group. Prospective research with rigorous methodology is needed to better understand long-term effect of statin use on the trabeculectomy outcome.
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