| 대한안과학회 학술대회 발표 연제 초록 |
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| Extended Report : 백내장 수술 시 각막내피세포 보호를 위한 온도감응성 고분자 하이드로겔의 적용 | |||||||
| 노원 빛사랑 안과¹, SNU청안과² | |||||||
| 최정열¹, 한영근² | |||||||
목적 : To evaluate the utility of thermoreversible (poloxamer) hydrogels as a substitute for ophthalmic viscosurgical devices (OVDs) during phacoemulsification, and to compare their endothelial protective effect with that of hyaluronic acid-based OVDs during phacoemulsification in porcine and rabbit eyes. 방법 : Fluorescein-stained poloxamer hydrogels [20, 22, 24, and 26% (weight/weight%)], and cohesive and dispersive OVDs were injected into the anterior chamber of porcine eyes incubated at 32°C. During continuous phacoemulsification under the endothelium, the retention time was measured in 45 porcine eyes classified into three groups (n=15 eyes/group). The endothelial cell count was measured before and 3 days after intermittent phacoemulsification in 12 rabbit eyes randomized into a poloxamer hydrogel group and a dispersive OVD group. 결과 : The optimal concentration of thermosensitive hydrogel was 26%, at which no gel-to-sol phase transition was observed in the anterior chamber, with a 21°C irrigation solution. The mean retention times (mean ± standard deviation) were 5.53±1.77 s, 125.00±29.34 s, and 221.53±42.48 s in the cohesive OVD, dispersive OVD, and 26% poloxamer hydrogel groups, respectively (p<0.001). 결론 : Thermoreversible hydrogels are potentially suitable material for corneal endothelial protection during phacoemulsification as substitutes for hyaluronic acid-based OVDs. |
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