| International FP-003 |
| Rate of Three-Dimensional Neuroretinal Rim Thinning in Glaucomatous Eyes with Optic Disc Hemorrhage |
| Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea (1)
Department of Ophthalmology, Hanyang University Hospital, Seoul, Korea (2)
Department of Ophthalmology, VHS Medical Center, Seoul, Korea (3)
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| Yong Woo Kim(1), Won June Lee(2), Bo Ram Seol(3), Young Kook Kim(1), Jin Wook Jeoung(1), Ki Ho Park(1) |
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Purpose : To investigate the thinning rate of three-dimensional neuroretinal rim thickness (3D-NRT) in glaucoma eyes with optic disc hemorrhage (DH) and its relationship to retinal nerve fiber layer thickness (RNFLT) and visual field (VF) progression
Methods : Seventy-five (75) eyes of 75 glaucoma patients with initial DH in inferotemporal area and 48 eyes of 48 glaucoma patients without DH were retrospectively reviewed. The rates of change for 3D-NRT, RNFLT, and VF parameters were compared by linear mixed-effect model. For the direct comparison between 3D-NRT and RNFLT, dynamic range based normalized coefficient was used. Factors influencing the rates of 3D-NRT and RNFLT thinning were evaluated.
Results : During more than 7 years of follow-up, the rates of thinning of 3D-NRT (–6.20 ± 4.76 µm/yr) and RNFLT (–2.17 ± 2.01 µm/yr) correspondent to the site of DH were faster than those at other locations (all Ps < 0.05). The dynamic-range-based normalized rate of thinning was significantly faster for RNFLT (–2.15 ± 1.53 %/yr) than for 3D-NRT (–1.09 ± 1.07 %/yr, P < 0.001). DH frequency was associated with the thinning rate of RNFLT but not with 3D-NRT. VF progression rate was not correlated with the rate of thinning of 3D-NRT or RNFLT.
Conclusion : 3D-NRT progression was fastest at the site of DH and was correlated with RNFLT but not with VF progression. Based on dynamic-range-based normalization of each measurement, 3D-NRT progressed more slowly than did RNFLT.
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