| International FP- 009 |
| Association of Disorganization of Retinal Inner Layers(DRIL) With Visual Acuity Response to Intravitreal Dexamethasone Implant for Macular Edema Secondary to Central Retinal Vein Occlusion(CRVO) |
| Department of Ophthalmology, School of medicine, Gyeongsang National University(1)
Department of Ophthalmology, School of medicine, Chosun University(2) |
| Woong-Sun Yoo(1), Hyun-Ji Kang(1), Ji-Seong Jeong(1), Min-Ho Shin(2), Jong-Moon Park(1), Inyoung Chung(1) |
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Purpose : To examine whether DRIL at baseline and after treatment is associated with visual acuity in patients with macular edema secondary to CRVO who were treated with intravitreal dexamethasone implant.
Methods : The retrospective review of records of 22 patients with treatment-naive CRVO with center involved macular edema treated with intravitreal dexamethasone implant. Spectral domain optical coherence tomography (SD-OCT) images were obtained from each visits. The DRIL extent and additional parameters were evaluated in the 2000um-wide foveal centered area
Results : In the 22 patients (mean age = 74.5±8.92), baseline DRIL was seen in 21 eyes (94.5%). In univariate analysis, baseline best corrected visual acuity(BCVA) was significantly associated with baseline DRIL extent(p=0.005, r=-0.58), and extent of external limiting membrane disruption and ellipsoid zone(p=0.015, r=-0.51; p=0.011, r=-0.533 respectively). Final BCVA related statistically significant with baseline BCVA(p<0.001, r=0.74) and DRIL extent(p=0.04, r=-0.35). Change of BCVA was associated with change of DRIL between baseline and final visit(p=0.041, r=-0.439).
Conclusion : Baseline DRIL extent and DRIL change after treatment with intravitreal dexamethasone implant for macular edema secondary to CRVO may be useful parameter of visual acuity improvement.
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