| International FP-013 |
| 10 year-longitudinal investigation of the power vector analysis in astigmatism, and its association with a genetic variation: The Yamagata Study (Funagata). |
| Yamagata university(1), Yamagata prefectural central hospital(2), Yamagata university; Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology(3), Yamagata university; Department of Advanced Medicine(4) |
| Hiroyuki Namba(1), Akira Sugano(1), Takanori Murakami(2), Koichi Nishitsuka(1),Kenichi Ishizawa(3), Takamasa Kayama(4), Hidetoshi Yamashita(1) |
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Purpose : To investigate the ageing-related shift towards against-the-rule (ATR) astigmatism over a period of 10 years, and its association with a genetic variation.
Methods : We included 271 Japanese participants who had undergone systemic and ophthalmological examinations in the periods 2005—2007 (phase 1), 2010—2012 (phase 2), and 2015—2017 (phase 3) in Funagata town, Yamagata, Japan. The participants were divided into 5 groups according to the age at phase 1. Astigmatism was evaluated using power vector analyses where J0 represents the power of the orthogonal astigmatism. Positive values of J0 indicate with-the-rule astigmatism, while negative values indicate ATR astigmatism. We investigated the association between ATR shift and leukocyte immunoglobulin-like receptors A2 (LILRA2) gene variants detected from 51 single nucleotide variants (SNVs).
Results : Both, J0 and corneal J0 (cJ0) declined over the period of 10 years (both P < 0.001). Although astigmatic shifts towards ATR were demonstrated in some age-divided groups in J0 and cJ0, there were no significant changes in the 30s and 70s age groups of J0 over a period of 10 years. ATR shift in LILRA2 rs2241524 A/A genotype was larger than those in G/G or A/G genotypes.
Conclusion : The refractive and keratometric shifts toward ATR astigmatism with aging were confirmed in a longitudinal study. Homozygous mutation of LILRA2 rs2241524 was also associated with ATR astigmatism.
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