| International FP-001 |
| Mediators of corneal haze after presbyopic inlay surgery |
| Singapore National Eye Centre, Singapore(1)
Singapore Eye Research Institute, Singapore(2)
Eye Academic Clinical Program, Duke-NUS Graduate Medical School, Singapore(3)
Department of Statistics and Applied Probability, National University of Singapore(4)
Neuroscience Signature Research Program, Duke-NUS Graduate Medical School, Singapore(5)
Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore(6)
Eagle Eye Centre, Singapore(7) |
| Beau J. Fenner(1,2), Yu-Chi Liu(1,2,3), Siew Kwan Koh(2), Yan Gao(2), Lu Deng(4), Roger W. Beuerman(2,3,5), Lei Zhou(2,3,6), Julian T. S. Theng(7), and Jodhbir S. Mehta(1,2,3) |
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Purpose : To identify protein mediators of corneal haze following presbyopic corneal inlay surgery.
Methods : Tears were collected from eyes with corneal haze following surgery with the Raindrop presbyopic corneal inlay. Samples underwent tear proteomics analysis and proteins up- or down-regulated in haze eyes relative fellow eyes were identified. Expression ratios were compared to postoperative eyes without corneal haze to identify proteins selectively regulated in corneal haze eyes.
Results : Inlay-associated haze occurred in 35% of eyes. Of almost 1,500 unique tear proteins identified, eight proteins were reduced in tears from post-operative haze eyes and one protein increased. Proteins reduced in haze eyes included C4a, CFH, Ig-kappa 2-29 and 2D-28, Ig-lambda 7-46, S100 calcium binding protein A4, Shootin-1, and TIMP-1. The Xaa-Pro aminopeptidase 1 was increased in haze eyes relative to non-haze eyes.
Conclusion : Corneal haze following corneal inlay surgery is associated with reduced levels of inflammatory and immune mediators. These findings represent a starting point for elucidation of pathways involved in corneal haze following synthetic inlay implantation and may enable development of targeted therapies that suppress the haze response.
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