| International FP-010 |
| Comparison of Central Corneal Thickness & Intraocular Pressure between Pre-menopause and Post-menopause Women with No Dry Eyes |
| Department of Ophthalmology, Hospital Tuanku Ampuan Najihah, Kuala Pilah, MALAYSIA(1) |
| Sivagurunathan-Premala Devi(1), Muhamad Firdaus-Z(1), Zakwan-I(1), Puspha R(1), Mohd Khalid-KH(1) |
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Purpose : Presence of female reproductive hormone receptors in human corneas has been demonstrated in several studies and therefore these sex hormones may influence the biological function of corneal tissue and intraocular pressure (IOP). The objective of this study is to compare the mean central corneal thickness (CCT) and IOP between pre-menopausal and post-menopausal women.
Methods : A total of 90 eyes of 50 pre-menopausal and 40 post-menopausal women underwent CCT measurement using optical method by ZEISS IOL Master 700. Participants of both groups met the inclusion and exclusion criteria, had no ocular co-morbidity and no dry eyes. Statistical analysis was performed using analysis of covariance with SPSS version 23.
Results : The mean age in pre-menopause women is 36.6 years and post menopause is 53.5years. There’s a significant difference in age between the two groups (p<0.001). The mean CCT in pre-menopause women is 536.8µm and post menopause women is 530.8µm. After adjusting for age, there’s a significant difference in the mean central corneal thickness between the two groups with pre-menopausal women having thicker central corneal thickness than post-menopausal women (p =0.018).
The mean IOP in pre-menopause women is 14.4mmHg and post-menopause women is 15.9mmHg. After age adjustment, there is marginally no significant difference in the mean IOP between pre-menopause and post-menopause women (p=0.051).
Conclusion : In post-menopausal women with no dry eyes, the absence of vital female reproductive hormones did affect the CCT but not the IOP. However, in view of marginal insignificance in the IOP between two groups, a larger sample size might provide a clear difference of IOP between pre-menopause and post-menopause women.
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