|
목적 : To investigate the efficacy and safety of long-term treatment with topical 0.02 % tacrolimus ointment for ocular inflammation in children under 18 years old
방법 : Seventy two patients under 18 years (mean age 10.79 (± 3.96) years) old who were prescribed 0.02% tacrolimus ointment in ophthalmology clinic from Jan 2010 to Mar 2018 were included in the study. Long-term maintenance treatment (≥6 months) with topical 0.03% tacrolimus ointment was applied to patients with ocular GVHD (Graft-versus-host disease), VKC (Vernal Keratoconjunctivitis), allergic conjunctivitis, and corneal phlyctenulosis. Patients were evaluated with a questionnaire and slit-lamp examination after treatment, and symptoms and signs were compared to those observed at baseline.
결과 : Seventy two patients were treated with tacrolimus ointment. Seven patients did not follow up. Except for burning sensation, there were no reported side effects. Six of 65 patients experienced intolerable burning sensation, which required treatment cessation. Cessation days of those who quit were 1,5,14,35,38, and 109 days. Twenty five of 65 patients fully recovered, resulting in discontinuance of the ointment treatment before 6 months. Thirty four patients consisted of nineteen males (56 %) and fifteen females (44 %) were treated with tacrolimus ointment for over 6 months
결론 : Long-term maintenance of topical 0.02 % tacrolimus ointment is a safe and useful treatment in children under 18 years old to treat GVHD, VKC, allergic conjunctivitis, and corneal phlyctenulosis
|