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목적 : To investigate the presence of hyperreflective foci (HF) and their association with dyslipidemia in serous retinal detachment (SRD)-type diabetic macular edema (DME) to support the idea that HF on optical coherence tomography (OCT) findings of DME patients could be indicative of activated microglia.
방법 : Thirty-three eyes in 31 patients with diabetic retinopathy (DR) and 22 eyes in 22 patients with branch retinal vascular occlusion (BRVO) showing macular edema were included in this study. The medical records and OCT findings were retrospectively reviewed in patients with SRD-type DME and compared with those with BRVO. The mean number of HF, the mean choroidal thickness, and lipid profiles were analyzed and compared between groups.
결과 : The mean number of HF and the mean choroidal thickness were significantly higher in DR group compared to BRVO group. Significant correlation of HF were noted with total cholesterol (r = 0.496, P = 0.006), as well as with triglycerides (r = 0.639, P = 0.002). Among lipid profiles, triglycerides remained significantly associated with HF by multiple linear regression (β = 0.004, 95% CI: 0.001 – 0.019, P = 0.030).
결론 : HF on OCT of DME patients could be indicative of activated microglia. HF are associated with dyslipidemia, especially high triglycerides, suggesting inflammatory reaction from dyslipidemia in diabetic retina. Further studies concerning the effect of lipid-lowering therapy to HF and associated inflammation may be needed.
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