|
목적 : To investigate the relationship between the lamina cribrosa (LC) curvature and the microvasculature within the LC in treatment-naïve eyes with normal-tension glaucoma (NTG) and in healthy eyes.
방법 : Forty-one eyes of 41 treatment-naïve NTG patients and 41 age- and sex-matched healthy control eyes were included. The optic nerve head (ONH) area was scanned using spectral-domain optical coherence tomography (OCT) by an enhanced depth-imaging technique to examine the LC curvature quantified as the LC curvature index (LCCI). OCT angiography of the ONH area was performed on the same day to determine the LC vessel density (LCVD) in the en-face images obtained from the layer segmented at the level of the LC.
결과 : The LCCI was larger (9.53±1.33 vs. 6.55±1.02, P<0.001) and LCVD was smaller (28.0±6.1% vs. 35.2±6.3%, P<0.001) in NTG eyes than in healthy eyes. There were overall significant associations of a smaller retinal nerve fiber layer (RNFL) thickness (P<0.001) and a larger LCCI (P=0.004) with a smaller LCVD. In the NTG group, the LCVD was positively associated with the RNFL thickness (P=0.012) and negatively associated with the axial length (P=0.013) and LCCI (P=0.007). In the healthy group, a smaller RNFL thickness (P=0.023) was associated with a smaller LCVD.
결론 : A larger LCCI was significantly associated with a smaller LCVD in treatment-naïve NTG eyes but not in healthy eyes, indicating that mechanical strain potentially influences the perfusion within the LC in eyes with NTG.
|