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목적 : To investigate the clinical characteristics of patients showing discrepancy between Bruch’s membrane opening minimum rim width (BMO-MRW) and peripapillary retinal nerve fiber layer (RNFL) thickness and its correlation with visual field (VF) in the diagnosis of early glaucoma.
방법 : In this prospective, cross-sectional study, 106 eyes (106 subjects) out of 111 eyes showing normal BMO-MRW classification but abnormal RNFL classification were included. Five subjects with poor image and post-intraocular surgery were excluded. All patients underwent standard ophthalmic examinations including confocal scanning laser tomography, Spectralis spectral-domain optical coherence tomography, and standard automated perimetry. Included eyes showed large disc (> 2.43 mm2): 40.6%, small disc (< 1.63 mm2): 12.5%, and regular disc: 46.9%.
결과 : Clinical characteristics are as follow; Mean age:52.79±14.75, female:37.7%, spherical equivalent(SE):-2.52±3.48D, SE<-5.0D:34 eyes(32.1%), baseline intraocular pressure:15.20±3.17mmHg,VF index:96.72±9.58%, mean deviation:-1.74±3.61dB, β-peripapillary atrophy(PPA): 96.2%, γ-PPA:75.5%, glaucoma hemifield test of within normal limits(WNL), borderline, outside normal limits: 71.3%, 13.8%, 14.9%. T and IN RNFL showed significant differences among disc size groups(all p<0.05). T, ST, IT, IN RNFL, and superior RNFL peak location showed significant differences(all p<0.05) among three SE groups.
결론 : Temporalization of RNFL peaks in myopia and nasalization of RNFL peaks in large disc which display abnormal classifications may show normal classification of BMO-MRW. Majority of these cases may demonstrate WNL of VF test. These findings should be taken into consideration in the diagnosis of early glaucoma which may cause confusion from discrepancy of the two structural test results. BMO-MRW may reflect neuroretinal rim tissue more accurately than RNFL in the diagnosis of early glaucoma.
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