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목적 : To evaluate the efficacy of anti-vascular endothelial growth factor (VEGF) treatment in eyes with foveal serous retinal detachment (SRD) associated with inferior staphyloma and to investigate the choroidal thickness changes following anti-VEGF therapy.
방법 : In this observational case series, eyes with inferior staphyloma accompanied by foveal SRD were treated with a single intravitreal anti-VEGF injection, followed by further injections as needed. Changes in subretinal fluid (SRF) and visual acuity after treatment were assessed. Choroidal thickness was measured at the subfovea, 1.5 mm superior and inferior to the fovea using enhanced depth imaging OCT at baseline and 1 month after initial anti-VEGF therapy.
결과 : Six eyes from six patients were included. One month after the initial injection, the mean SRF height and width had decreased significantly from 112.5±40.1 to 44.5±48.7 µm (P=0.046), and from 1401.8±627.3 to 690.7±634.7 µm (P=0.028), respectively. The mean choroidal thickness at the superior point decreased from 218.7±59.3 to 200.5±61.0 µm (P=0.046). The SRF completely resolved in 3 of the 6 eyes with a mean of 6.8±5.9 injections. All eyes experienced at least one recurrence of exudation, at a mean interval of 4.8 months. The mean visual acuity improvement was 0.17 logMAR units.
결론 : Anti-VEGF therapy resulted in an SRF decrease and modest visual improvement in eyes with foveal SRD associated with inferior staphyloma. Reduction of the superior choroidal thickness seemed to be involved in the clinical improvements.
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