| 발표일자: |
2019년 4월 5일(금)~7(일) |
| 발표번호: |
P-060 |
| 발표장소: |
벡스코 전시장 1홀 내 |
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| Nuances in pathological evidence for Bilateral Diffuse Uveal Melanocytic Proliferation(BDUMP) |
| Sri Sankaradeva Nethralaya, Guwahati Assam, India
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| AWANEESH UPADHYAY(1), DIPANKAR DAS (2), DIVAKANT MISRA(3) |
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Purpose : To present cases of enucleated eyeballs with conditions of Diffuse Uveal Melanocytic Proliferation
Methods : A case series
Results : Case 1: An 80 years old Indian lady presented with dimness of vision (DOV) in left eye (OS) for 1 month. Vision was perception of light negative in OS. Fundus examination revealed a choroidal mass in OS. Ancillary imaging gave the diagnosis of choroidal melanoma in OS. Ultrasound of neck showed a colloid nodule in the thyroid with abnormal liver function test; Enucleated eyeball showed evidence of DUMP with interesting changes of melanocytic proliferations in around retinal vessels, layer of retina with characteristic sparing of choriocapillaries. Immunohisto chemistry (IHC) was done with various markers. Other eye fundus examination had retinal pigment epithelial defect and she is under follow-up with oncologist for thyroid nodule. Case 2: A 28 years old man with DOV in OD for 5 months. Previously, he was diagnosed to have ulcerative colitis (UC) with GIT polyps. Ocular imaging showed the patient having diffuse choroidal mass. Enucleated eyeball revealed the evidence of DUMP with interesting gross, histopathology and IHCs findings. He is under the follow-up with gastroenterologist for UC and is on immunosuppressive. OS was clinically normal but scotopic electroretinography was minimally abnormal
Conclusion : Angiocentric melanocytic proliferations with IHC supported evidence in BDUMP were some of the newer observations that were seen in the study.
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