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목적 : To determine longitudinal changes in the peripapillary retinal nerve fiber layer (pRNFL) thickness in patients with hypertension (HTN).
방법 : Design: A prospective observational study.
Participants: Participants without any ophthalmic disease were divided into two groups: a HTN group (50 eyes) that included patients with HTN for ≥ 5 years and a control group.
Methods: After the initial visit, pRNFL thicknesses were measured four more times at 1-year intervals using spectral-domain optical coherence tomography. The pRNFL thickness was fitted using linear mixed models. Univariate and multivariate generalized linear mixed models were used to determine factors associated with pRNFL reductions over time.
결과 : The mean pRNFL reduction rate was -1.14 and -0.40 μm/year in the HTN and control groups, respectively; the interaction between group and duration was significant (P < 0.001). In the HTN group, all sectors showed a significant reduction over time, but in the control group, only the superior sector showed a significant reduction over time. In the linear mixed model determination of factors associated with pRNFL reduction, age, and axial length showed significant results in both univariate and multivariate analyses (estimate: -0.43 and -3.59; P = 0.016 and 0.005, respectively).
결론 : Patients with HTN had a significantly greater decrease in pRNFL than normal individuals. Additionally, age and axial length significantly affected the reduction in pRNFL in HTN patients.
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