| EP F-004 |
| Correlations between Optical Coherence Tomography Angiography (OCT-A) and Multifocal Electroretinography (mfERG) Findings in Diabetic Retinopathy Patients |
| Department of Ophthalmology, College of Medicine, Soonchunhyang University, Cheonan, Korea(1)
Department of Ophthalmology, College of Medicine, Soonchunhyang University, Bucheon, Korea(1) |
| Hoon Dong Kim(1), Jina Kim(2), Sanjar Madrahimov(2), Ka Hee Park(2), Young-Hoon Ohn(2) |
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목적 : To assess morphological and functional changes of macula in subjects with normal and abnormal fundus with diabetic retinopathy using optical coherence tomography angiography (OCT-A) and multifocal electroretinography (mfERG).
방법 : OCT-A and mfERG were performed on 32 eyes with non-proliferative diabetic retinopathy (NPDR group), 33 eyes with proliferative diabetic retinopathy (PDR group), and 33 normal controls. Foveal avascular zone (FAZ) area, vessel density (VD), perfusion of superficial and deep capillary plexus (SPC, DPC) were estimated using OCT-A. The mean N1 and P1 amplitudes in the Ring 1 were obtained from mfERG. The correlations between OCT-A results and mfERG parameters were analyzed in 3 groups including NPDR, PDR, and normal controls.
결과 : The mean FAZ areas were 0.38±0.10 mm2 in normal controls and 0.33±0.15 mm2 in NPDR group, 0.26±0.18 mm2 in PDR group, respectively. Central VD and central DPC were significantly decreased with step-wise pattern as the stage of diabetic retinopathy progresses. The mean amplitudes of N1 and P1 from Ring 1 were reduced significantly in NPDR and PDR groups compared to normal controls. Vessel density and perfusion parameters showed significantly correlations with P1 amplitudes according to severity of diabetic retinopathy, however, FAZ area revealed no apparent correlation with mfERG results.
결론 : VDs and perfusion parameters were decreased in eyes with diabetic retinopathy compared to normal controls. mfERG responses were decreased in diabetic retinopathy with step-wise pattern. In addition, several correlations between OCT-A and mfERG findings were also identified. These results suggest that OCT-A and mfERG were useful tools to investigate the morphologic and functional alteration of the patient with diabetic retinopathy.
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