| EP F-002 |
| Assessments of electrophysiologic changes in experimental retinal degeneration induced by intravitreal sodium iodate administration |
| Department of Ophthalmology, Hallym University College of Medicine(1), Department of Ophthalmology, Chung-Ang University College of Medicine (2), Department of Ophthalmology, Seoul National University College of Medicine (3)
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| So Hyun Bae(1), Bum-Joo Cho(1), Hum Chung(2), Jong-Mo Seo(3) |
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목적 : To investigate the dose-dependent electrophysiologic changes in experimental retinal degeneration induced by intravitreal sodium iodate (NaIO3) administration
방법 : Albino rabbits were administered unilateral intravitreal injections of NaIO3 at doses of 0.1, 0.2, 0.4 or 0.8mg (n=5 for each group). Ophthalmologic assessments including fundus examination, optical coherence tomography, full-field electroretinography (ERG) and histologic analysis were conducted from the baseline to day 28 after NaIO3 injection.
결과 : In the 0.1- and 0.2-mg groups, there were slight numerical reductions of a-wave amplitude in the early phase, which recovered completely after 14 days. Contrastingly, both groups showed complete abolishment of the b-wave in the early phase, which recovered fully after 7 days. In the 0.4-mg group, severe reduction of the a-wave amplitude was detected at 1 day, which was sustained without restoration. The b-wave also was abolished at 1 day, which was not recovered throughout the study. In the 0.8-mg group, the ERG responses were extinguished at 1 day and did not recover.
결론 : Electrophysiologic changes following NaIO3 administration are dose-dependent. Electrophysiologic impairment is reversible in low-dose NaIO3 groups, but do not recover in higher doses of NaIO3.
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