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목적 : To investigate the utility of selected pattern electroretinogram (PERG) parameters—including N95 amplitude and N95/P50 ratio, and a BL-N95 amplitude—in the analysis of visual function(s) and for predicting changes in retinal ganglion cell structures in optic neuropathies.
방법 : Forty-four eyes from 36 patients diagnosed with optic neuropathy were included. A BL-N95 amplitude was defined as the amplitude measured from baseline to the trough of N95. PERG and pattern visual evoked potential (pVEP) measures were acquired within 1 week after onset of optic neuropathies. To compare functional and anatomical changes, mean temporal peripapillary retinal nerve fiber layer (pRNFL) and average and minimum ganglion cell-inner plexiform layer (GC-IPL) thicknesses were measured using optical coherence tomography.
결과 : Both the N95 and BL-N95 amplitudes were significantly correlated with visual acuity (r=-0.38, p=0.010 and r=-0.32, p=0.029, respectively). Although P100 latency was not correlated with all PERG parameters, the N95 and BL-N95 amplitudes demonstrated a positive correlation with P100 amplitude in pVEP (r=0.32, p=0.032 and r=0.41, p=0.005, respectively). PERG parameters, including the N95 and BL-N95 amplitudes, and N95/P50 ratio, were not correlated with pRNFL thickness in OCT. Only the BL-N95 amplitude demonstrated a significant correlation with GC-IPL.
결론 : The BL-N95 amplitude―measured from baseline to the trough of N95―was valuable in the analysis of visual function(s) and for predicting changes in retinal ganglion cell structures in optic neuropathies.
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