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목적 : Rates of glaucomatous visual field (VF) progression is varies individually. We compared the posterior sclera configuration of eyes with progressive VF to the stable VF to investigate the factors associated with VF progression in myopic normal tension glaucoma (NTG).
방법 : Treated myopic NTG patients with 5 or more Swedish Interactive Threshold Algorithm Standard 24-2 VFs (Humphrey Field Analyzer; Carl Zeiss Meditec, Dublin, CA) in either eye were identified. Visual field progression was defined using the Early Manifest Glaucoma Trial criteria. Posterior sclera was represented by using the relative location of deepest point of the eyeball (DPE) from the optic disc by measuring the distance, depth, and angle using the swept source optical coherence tomography (OCT). The Cox proportional hazards model was used to determine the risk factors for VF progression.
결과 : Among 76 eyes, 38 showed VF progression. While age, axial length, mean follow-up intraocular pressure (IOP), IOP fluctuation, IOP reduction from baseline, baseline VF examination, baseline retinal nerve fiber layer (RNFL) thickness were not significantly different, the posterior sclera configuration were significantly different in the distance, depth, and angle of the DPE position (p=0.049, p=0.032, and p=0.006, respectively). A multivariate Cox proportional hazard model revealed that the DPE position temporal to the fovea (HR: 4.314, p=0.001) were associated with VF progression.
결론 : The posterior sclera configuration may be an important prognostic factor in patients with myopic NTG.
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