|
목적 : To investigate whether the use of early topical anti-glaucoma medication affects wound healing following glaucoma tube surgery.
방법 : Eyes were randomly assigned to receive topical aqueous suppressant (timolol-dorzolamide fixed combination) or prostaglandin analogue (travoprost) or normal saline (control group). First, we observed the effects of topical eyedrops on Tenon’s tissue in non-operated eyes in adult New Zealand white rabbits. Secondly, other rabbits had glaucoma drainage device implantation using Model FP 8 Ahmed glaucoma valves.
결과 : In non-operated eyes, IOP was similar among the groups (P=0.545). Interleukin-2 in the Tenon’s tissue was higher in the PG group than in the control or aqueous suppressant groups (P=0.006). After glaucoma implant surgery, IOP was lower in the aqueous suppressant group than in the control or the PG group (P=0.001). Mean height of the inner collagenous layer and the average height of α-SMA-positive blebs was the least in the aqueous suppressant group (P=0.013, P=0.001, respectively) at 4 weeks postoperative.
결론 : In the glaucoma drainage device surgery, early treatment of aqueous suppressant decreased fibrosis in the bleb whereas early treatment with the PG analogues did not.
|