| GL F-003 |
| Temporal Raphe Sign for Discrimination of Glaucomatous from Non-Glaucomatous Optic Neuropathy in Eyes with Macular Ganglion Cell-Inner Plexiform Layer Thinning |
| 1 Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea
2 Division of Glaucoma, Department of Ophthalmology, Seoul National University Hospital (SNUH), Seoul, Korea
3 Division of Neuro-Ophthalmology, Department of Ophthalmology, SNUH, Seoul, Korea
4 Department of Ophthalmology, Kyungpook National University School of Medicine, Daegu, Korea
5 Division of Glaucoma, Department of Ophthalmology, Kyungpook National University Hospital, Daegu, Korea |
| Jinho Lee(1,2), Young Kook Kim(1,2), Ahnul Ha(1,2), Yong Woo Kim(1,2), Sung Uk Baek(1,2), Jin-Soo Kim(1,2), Haeng Jin Lee(1,3), Dai Woo Kim(4,5), Jin Wook Jeoung(1,2), Seong-Joon Kim(1,3), and Ki Ho Park(1,2) |
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목적 : To evaluate the potential of the temporal raphe sign on the macular ganglion cell-inner plexiform layer (mGCIPL) thickness map for discriminating glaucomatous from non-glaucomatous optic neuropathy in eyes with mGCIPL thinning.
방법 : Among 175 eyes of 175 patients who showed mGCIPL thinning on Cirrus high definition optical coherence tomography (HD-OCT), 67 eyes with glaucomatous optic neuropathy (GON) and 73 eyes with non-glaucomatous optic neuropathy (NGON) were enrolled. A positive temporal raphe sign was declared in cases where there was a straight line longer than one-half of the length between the inner and outer annulus in the temporal elliptical area of the mGCIPL thickness map. Decision tree analysis was performed in order to formulate a diagnostic model.
결과 : The temporal raphe sign was observed in 61 of 67 GON eyes (91.0%), but only in 21 of 73 NGON eyes (28.8%) (P < 0.001). The diagnostic ability of the temporal raphe sign for discriminating GON from NGON was judged to be good (AUC 0.811). The diagnostic performance of the decision-tree-based model (AUC 0.879) was better than that of either the temporal raphe sign or the relative afferent pupillary defect (RAPD) alone (P = 0.005, P < 0.001, respectively).
결론 : In clinical practice, determining whether the temporal raphe sign appears on OCT macular scans can be a useful tool for discrimination of glaucomatous from non-glaucomatous mGCIPL thinning.
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