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목적 : To investigate effect of refractive error on the physiologic thinning rate of retinal nerve fiber layer (RNFL) in healthy eyes
방법 : Retrospective study was performed on subjects who had been followed more than 5 years and underwent Cirrus HD-OCT more than 5times. Longitudinal RNFL measurements were analyzed with linear mixed models incorporating follow-up duration, baseline RNFL thickness, spherical equivalent, age, gender, IOP measurements, and visual field mean deviation. We compared thinning rate in three groups classified by spherical equivalent, non-myopic group (NMG, > 0 D), a mild to moderate myopic group(MMG, -6D< and <0 D) and a highly myopic group (HMG, -6 D >).
결과 : The mean rates of change of average, superior,temporal and inferior RNFL thicknesses were -0.389, -0.524, -0.316 and -0.778 um/year, respectively, after adjusting for gender, age, spherical error(SE), IOP, and visual field MD. The significant factors influencing the rates of change of RNFL measurements were gender and SE. Male and a higher IOP were associated with a faster rate of change. In a comparison of subgroups, after adjusting for coefficients, the thinning rates of average RNFL thickness in NMG, MMG, HMG were -0.305, -0.294, -0.208 um /year, and those were not significantly different.
결론 : In healthy eyes, RNFL thickness decreased with the rate of 0.305 μm per years. Refractive error did not affect the physiologic thinning rate.
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