| CO F-029 |
| Validation of Alternative Methods Detecting Meibomian Gland Dropouts without an Infrared Imging System: Red Filter for Simple and Effective Meibography |
| 1.Department of Cornea, External Disease & Refractive Surgery, HanGil Eye Hospital, Catholic Kwandong University College of Medicine, Incheon, Republic of Korea
2. Department of Ophthalmology, Hallym University College of Medicine, Chuncheon, Republic of Korea,
3. Department of Ophthalmology, College of medicine, The Catholic University of Korea, Republic of Korea |
| Sang-Mok Lee (1)Inwon Park (2),Yong Ho Goo(2), Dongchul Choi(2), Min Chul Shin(2), Eun Chul Kim(3), Man Soo Kim(3), Ho Sik Hwang(2) |
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목적 : To evaluate the validity and reliability of alternative methods for evaluating meibomian glands dropout without an infrared light system: either red-filtered or isolated red-channel images of the everted eyelid
방법 : We reviewed meibomians gland in the upper and lower eyelids of 125 eyes of 64 patients with good-quality infrared meibography images (IMI) and color digital photographs with and without a red filter. Red-filtered images (RFI) were converted to black-and-white and adjusted for contrast/brightness (aRFI). Red-channel images (RCI) were isolated computationally from color digital photographs obtained without a red filter. After randomization, the total meiboscore (0-6) was blindly evaluated by two independent evaluators, and again with a 30-day interval.
결과 : The meiboscore evaluated by RFI, aRFI, and RCI were strongly positively correlated with those evaluated by IMI (RFI: ρ=0.788; aRFI: ρ=0.735; RCI: ρ=0.630; all P’s< 0.001, Spearman's correlation analysis). Linear-weighted κ-values (κw) showed substantial agreement between RFI and IMI (κw=0.676, 95% CI=0.594-0.759). The RFI showed almost perfect intra-observer reliability (κw=0.81, 95% CI=0.749-0.871) and moderate inter-observer reliability (κw=0.592, 95% CI=0.508-0.676). Computational adjustment of RFI did not enhance the validity or reliability, and RCI showed limitations in some case
결론 : Meibomian glands were successfully visualized using a red filter on a slit lamp, and showed substantial agreement with visualization using the standard infrared method. Although inter-observer reliability was only moderate, this alternative technique may be useful for evaluating meibomian gland dropout when an infrared meibography device is not available.
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