| CO F-012 |
| Clinical results and utility of Herpesviruses multiplex polymerase chain reaction using aqueous humor in corneal endotheliitis with high intraocular pressure |
| Gyeongsang National University, Department. of ophthalmology¹, Gyeongsang National University, Department of laboratory medicine² |
| Mi-Hwa, Park1, Ji-Sung, Jeong1, Min-Chul, Cho2, Min-Ho, Shin1, Inyoung, Chung1, Seong-Wook, Seo1, Seong-Jae, Kim1 |
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목적 : To determine the association of herpesvirus infection in corneal endotheliitis with high intraocular pressure (IOP) using multiplex polymerase chain reaction (PCR) with aqueous humor.
방법 : In a retrospective observational study, immunocompetent patients living in South Korea with typical corneal endotheliitis, who had an IOP of 21 mmHg or greater, or who were treated with antiglaucoma medications were included. We performed multiplex PCR kit using aqueous humor to detect six herpesvirus DNAs in patients with corneal endotheliitis at initial visit. Forty-two eyes of 42 patients who were followed up for more than 6 months were analyzed.
결과 : Of the total 42 eyes, 16 were positive for multiplex PCR, and 3 had HSV1, 3 had VZV, 9 had CMV, and 1 had EBV. In eyes with coin-shaped or fine keratic precipitates (kps), high intraocular pressure, and low baseline endothelial cell count, multiplex PCR is more likely to show a positive result. On univariate analysis, male (P = 0.014), previous history of uveitic glaucoma (P = 0.048), and fine kps (P = 0.031) were associated with positive PCR result. On multivariate analysis, male (P = 0.010), previous history of uveitic glaucoma (P = 0.031) were associated with positive PCR result.
결론 : CMV was the most commonly detected virus in multiplex PCR in patients with corneal endotheliitis with high IOP. The positive rate of PCR was higher in males and in those with uveitic glaucoma history and fine kps.
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