| RE F-057 |
| Variations in disease expression according to the type of drusen in neovascular age-related macular degeneration |
| Department of Ophthalmology, Yonsei University College of Medicine |
| Junwon Lee, Min Kim, Christopher Seungkyu Lee, Sung Soo Kim, Hyoung Jun Koh, Sung Chul Lee, Suk Ho Byeon |
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목적 : To investigate the prevalence of pachydrusen, soft drusen, and subretinal drusenoid deposits (SDDs) in eyes with different neovascular age-related macular degeneration (nAMD) subtypes, determine the relationship between each drusen type and the choroidal thickness, and analyze the distinct clinical features of typical nAMD according to the drusen type
방법 : The 454 eyes of 454 patients with nAMD were retrospectively reviewed. The prevalence of each drusen type and the choroidal thickness according to the nAMD subtype was evaluated. For the typical nAMD group, various clinical features were evaluated using imaging modalities.
결과 : Pachydrusen were prevalent in the typical nAMD (40.4%) and polypoidal choroidal vasculopathy (PCV) (47.8%) groups and were not detected in the retinal angiomatous proliferation (RAP) group. For eyes with typical nAMD, the prevalence of choroidal vascular hyperpermeability, pachyvessels, and extrafoveal neovascularization was significantly higher in the pachydrusen group than in the soft drusen and SDD groups, while that of type 2 neovascularization and intraretinal fluid was significantly lower in the pachydrusen group than in the SDD group (P < 0.001 for all).
결론 : The prevalence of various drusen was different according to the nAMD subtypes, and each drusen type is strongly associated with the choroidal thickness. Typical nAMD shows distinct clinical features according to the accompanying drusen type.
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