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목적 : To determine longitudinal change of pRNFL thickness in patients with high myopia without ophthalmic disease.
방법 : Subjects were divided into two groups: a high-myopia group (80 eyes) that included eyes with an axial length ≥ 26.0 mm and a control group (80 eyes). Both groups were further divided into age subgroups by decade: 20s, 30s, 40s, and 50s. Each subgroup included 20 eyes. After initial visit, pRNFL thickness measurements were performed two times more with at least one year intervals between examinations using spectral-domain optical coherence tomography. The mean pRNFL thickness was fitted with linear mixed models.
결과 : The thickness of the pRNFL at the first visit were 90.16 ± 9.06 μm, and 96.80 ± 9.50 μm in the high-myopia and control groups, respectively. For individuals in their 50s, the reduction rate was -1.69 μm/year and -0.63 μm/year in the high-myopia and control groups, respectively; the interaction between group and duration was significant (P = 0.014). The reduction rate of individuals in their 40s was -1.70 μm/year and -0.48 μm/year in two groups, respectively; the interaction was also significant (P = 0.031). Among those 30s and 20s, no such significant interactions were observed.
결론 : Highly myopic eyes had a significantly greater decrease in pRNFL over 2 years than normal eyes. In addition, the reduction rate of pRNFL thickness was greater in older patients with high myopia, whereas similar values were shown in normal controls except individuals in their 20s.
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