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목적 : Our objective is to conduct an economic evaluation of various population-wide screening strategies for AMD among the South Korean population.
방법 : Using a Markov cohort model, we evaluated the cost-effectiveness of four AMD screening strategies (opportunistic examination, opportunistic treatment, systematic photography, and systematic examination) in comparison with status quo (no screening) for South Korean adults. We projected a life time horizon to study a hypothetical cohort of 100,00 persons of age 40 with and without AMD at baseline. The outcome measures were quality-adjusted life-years (QALYs) gained, cost from the societal perspective,
결과 : Opportunistic treatment was strongly dominated because it generated fewer expected QALYs but incurred greater expected cost than the other screening strategies. The mean lifetime expected costs were 11,009,850 KRW, 36,422,529 KRW, 39,747,697 KRW, and 43,400,998 KRW, and the mean QALYs gained were 36.98, 38.29, 38.95, 39.5, for no screening, opportunistic examination, systematic photography, and systematic examination, respectively.
결론 : Under the WTP threshold of 30,000,000 KRW per QALY, systematic examination by specialists is cost-effective for screening AMD in South Korean adults. Systematic photography and examination by non-specialists generates fewer expected QALY and cost compared to systematic examination.
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