| RE F-039 |
| Association of cerebral β-amyloid deposition with structural and functional alterations of retina in cognitively normal older adults: the results from the KBASE study |
| 1Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Republic of Korea, 2Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea |
| Sung Wook Park1, Min Soo Byun2, Jun Ho Lee2 , Dahyun Yi2, So Yeon Jeon2, Kang Ko2, Un Hyung Ghim1, Un Chul Park1, Dong Young Lee2, Hyeong Gon Yu1, for the KBASE Research group |
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목적 : Several studies reported the structural and functional alterations of retina in patients with Alzheimer’s disease (AD) dementia and mild cognitive impairment, suggesting the potential link between retinal changes and brain AD pathology. However, no studies have yet explored whether retinal alterations appear even in cognitively normal (CN) older adults with cerebral beta-amyloid (Aβ) deposition, i.e., individuals in the asymptomatic stage of AD. We aimed to investigate the relationship between cerebral Aβ deposition and the changes in retinal structure and function in CN older adults.
방법 : Total 60 CN older adults were recruited from the ongoing prospective cohort, the Korean Brain Aging Study of the Early Diagnosis and Prediction of Alzheimer’s Disease (KBASE). All participants underwent comprehensive clinical assessment and multimodal imaging including [11C]-Pittsburgh Compound–B PET, MRI, and APOE genotyping. Eligible individuals had complete ophthalmic examination including SS-OCT and mfERG.
결과 : Subjects with positive cerebral Aβ deposition (A+CN, mean age, 68.4 years) were older than those without cerebral Aβ deposition (A-CN, mean age, 75.2 years, P = 0.009). Visual acuity was lower in A+CN (mean logMAR, -0.012 than A-CN (mean logMAR, 0.071 , P =0.009). A+CN had significantly decreased macular thickness compared to A-CN, especially in inner four quadrants of ETDRS area. In addition, A+CN showed significantly lower RNFL thickness in the temporal, superior, and inferior quadrants than A-CN. Implicit time from ring 2 to ring 6 were significantly delayed in the A+CN compared to A-CN.
결론 : To the best of our knowledge, this is the first to reveal the association between cerebral Aβ deposition and the structural and functional alterations of retina in CN older adults. The results suggest that both structural and functional alterations occur even in asymptomatic stage of AD. Our findings provide clues for the potential use of retinal examination for the early detection of in vivo AD pathology in CN older adults.
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