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목적 : To evaluate the contribution of choroidal thickness (CT) to the pathogenesis of myopic macular degeneration (MMD) and the presence of plus lesions.
방법 : Sixty three eyes of 46 patients with high myopia (refractive error, ≤-6 diopters or axial length, 26.5 mm) were enrolled. Enhanced depth imaging spectral-domain optical coherence tomography (EDI SD-OCT) was performed to measure subfoveal, superior, inferior, nasal, and inferior CT. MMD was graded from fundus photographs according to the International Meta-Analysis for Pathologic Myopia (META-PM) classification. Three additional features called ‘plus lesions’ included lacquer cracks, myopic choroidal neovascularization (mCNV) and Fuchs’ spot.
결과 : The distribution of MMD severity was 18 (28.6%) in category 1, 23 (36.5%) in category 2, 16 (25.4%) in category 3, and 6 (9.5%) in category 4. Plus lesions appeared 0 (0.0%) in category 1, 8 (32.0%) in category 2, 12 (48.0%) in category 3, and 5 (20.0%) in category 4. Multivariable analysis adjusted for age, gender, and spherical equivalent showed an association between CT with the development of MMD (β=-0.006 , p=0.001) and the presence of plus lesions (OR, 0.974; 95% CI, 0.949-1.000, p=0.048).
결론 : We demonstrated significant thinning of the choroid with increasing MMD severity and plus lesions. These data suggest progressive loss of choroid may be important in the progression of MMD and the occurrence of plus lesions.
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