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목적 : To evaluate the choroidal vascular area and density in eyes with polypoidal choroidal vasculopathy (PCV) using ultra-widefield (UWF) indocyanine green angiography (ICGA).
방법 : 16 eyes with PCV and 7 age-matched control (13 eyes) were included and imaged using UWF FA and ICGA. All UWF images were stereographically projected and binarized by threshold and Niblack’s method for the quantification of vascular areas. The choroidal vascular areas were calculated by subtracting vascular areas of FA images from those of ICGA images. The calculated choroidal vascular area and vascular density were compared among each groups from three different areas (<3 mm, 3~10mm, and 10~15mm, >15mm zones), and correlated with clinical findings and subfoveal choroidal thickness.
결과 : Compared with control eyes, PCV contained greater choroidal vascular area in <3 mm and 3~10 mm zone (p=0.04 in <3 mm zone/ p=0.03 in 3~10 mm zone). Compared with control eyes, PCV showed thicker choroid layer (p<0.005l) The choroidal vascular density was significantly correlated with subfoveal choroidal thickness, especially in Haller’s layer (P=0.017, rho=0.587 in choroidal thickness; P=0.022, rho 0.567 in Haller’s layer) For PCV, Good responders after 3 times of intravitreal anti-VEGF injection showed significantly lower choroidal vessel density at baseline than poor responders.(p=0.0049)
결론 : Subtraction and binarization of projected UWF FA and ICGA images can visualize the structure of the choroidal vessels and enable their quantification. In the eyes with PCV, choroidal vascular area and density increased, especially in the posterior zone, compared with control eyes. Choroidal vessel density is related with anatomical good responders in PCV. They may serve as diagnostic clues or even predictors of disease course.
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