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목적 : To determine the prevalence and incidence of keratoconus, and examine its association with common systemic diseases using a nationwide cohort.
방법 : This retrospective nationwide cohort study included 1,025,340 subjects from the Korean National Health Insurance Service National Sample Cohort database from 2004 to 2014. Estimates for prevalence and incidence rates of keratoconus were identified. After 1:5 matching using propensity scores, associations between keratoconus and certain systemic comorbidities were determined using a multivariate logistic regression analysis.
결과 : The prevalence of keratoconus in South Korea from 2004 to 2014 was 134.1 cases per 100,000 people, and the incidence during the same period was 15.1 cases per 100,000 person-years. Adjusted logistic regression analysis after propensity score matching revealed significant association between keratoconus and allergic rhinitis (odd ratio [OR] = 1.86, 95% confidence internval [CI] 1.63 - 2.13, p < 0.001) , asthma (OR = 1.20, 95% CI 1.06 - 1.36, p < 0.001), atopic dermatitis (OR = 1.33, 95% CI 1.13 - 1.56, p < 0.001), and DM (OR = 1.35, 95% CI 1.15 - 1.58, p < 0.001).
결론 : Estimates of prevalence and incidence of keratoconus may help planning eye care policies, and the results of this study inflict the association between allergic diseases and keratoconus. Conflicting results regarding the association between keratoconus and DM should be further evaluated.
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