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목적 : To determine changes in peripapillary retinal nerve fiber layer, central macular, and ganglion cell-inner plexiform layer thicknesses in patients with acute anterior uveitis.
방법 : Patients diagnosed with unilateral non-infectious acute anterior uveitis were enrolled. Optical coherence tomography scans were performed during the initial active phase and inactive phase of acute anterior uveitis. Patients were followed for at least 3 months after resolution of inflammatory activity to assess the changes in pRNFL, macular, and GC-IPL thickness.
결과 : A total of 37 patients were included. The average pRNFL thicknesses of affected eyes and fellow eyes during the active phase were 109.4 ± 12.5 μm and 96.5 ± 8.0 μm, respectively; (P < 0.001). During the inactive phase, there was no significant difference in pRNFL thickness between affected and fellow eyes (P = 0.236). The central macular thicknesses of affected and fellow eyes during the active phase were 261.6 ± 24.7 μm and 251.5 ± 17.3 μm, respectively; the difference was significant (P = 0.047).
결론 : The pRNFL and central macula thickened during the active phase of AAU and decreased to a similar degree with fellow eyes during the inactive phase. Additionally, pRNFL thickness showed a sensitive response to the degree of inflammation in AAU. This suggests that pRNFL thickness may be useful in assessing disease activity.
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