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목적 : We investigated the effects of recession and resection surgery of extraocular muscle (EOM) on satellite cell activity in rabbit
방법 : Sixteen eyes of 8 rabbits were included in this study. The superior rectus in the right eye was recessed or resected. Recession and resection surgery performed in 4 and 4 rabbits, respectively. Recession and resection surgery were performed at 5 and 10 mm and at 4 and 8 mm from original insertion, respectively. The superior rectus (operated muscle), inferior rectus (antagonist muscle) and superior rectus in the contralateral eye (control) were extracted after 4 weeks of operation. Z-Z band length, PAX7 activity and gene expression were measured.
결과 : Z-Z band length of operated and antagonist muscle after resection surgery were shorter than those after recession surgery (p < 0.01, all). PAX7 activity in operated muscle was higher than that in antagonist muscle (p < 0.01). PAX7 activity in operated and antagonist muscle after resection surgery was higher than after recession surgery (p = 0.03, 0.02). Myf5 and MyoG expression in operated muscle was higher than that inantagonist muscle (p = 0.02, < 0.01, respectively).
결론 : Activation and regeneration of satellite cell in operated and antagonist muscle after resection surgery increased more than those after recession surgery. These changes in satellite cells of EOM may explain postoperative alignment of EOM after strabismus surgery.
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