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목적 : To investigate the relationship between central visual field (VF) and macular parameters obtained from spectral-domain optical coherence tomography (SD-OCT) in end-stage glaucoma eyes who reach to circumpapillary retinal nerve fiber layer (cpRNFL) thickness measurement floor and to determine whether SD-OCT are useful for estimating functional status in these patients.
방법 : A total of 68 eyes from 68 patients with end-stage glaucoma were included. Only eyes with average cpRNFL of 57μm or less, that reached the measurement floor, were enrolled in this study. Macular imaging using Cirrus SD-OCT and 10-2 Humphrey visual field (VF) were performed. VF mean deviation (MD) was converted to linear scale using unlogged 1/Lambert values. The relationships between the central VF and the various macular parameters were determined using Spearman correlation analysis.
결과 : Patients had a mean VF MD of -20.69 decibel (dB) and average cpRNFL of 51.76 ± 3.61 μm. Correlations between central VF with all cpRNFL thickness parameters were not significant. Significant correlations were found between central VF and superonasal macular ganglion cell-inner plexiform layer (mGCIPL) thickness (r = 0.377, P = 0.002), inner nasal macular thickness (r = 0.305, P = 0.011), and outer nasal macular thickness (r = 0.314, P = 0.009).
결론 : Although the cpRNFL has reached the measurement floor, several macular parameters showed strong structure-function relationship. In particular, nasal macular region is important for assessing the central visual function in end-stage glaucoma.
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