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목적 : To provide the association between retinal vascular occlusion and dementia in the context of aging and vascular risk factors among Koreans.
방법 : Retrospective cohort study was performed from the National Health Insurance Service and comprised 380,540 random subjects. Patients who were diagnosed as new RVO from 2009 to 2014 were included. Individuals younger than 40 years of age and those with other cognitive diseases were excluded. Cox proportional hazard regressions were used to calculate the overall survival rate for dementia development after adjusting for potential confounders including body index index, diabetes mellitus, and dyslipidemia.
결과 : The risk factors for RVO was BMI, HTN, DM, smoking, exercise, drinking and dyslipidemia. (BMI, P<0.0001; HTN, P<0.0001; DM, P<0.0001; Smoking, P<0.0001; Exercise, P<0.0001; Drinking, P<0.0001; Dyslipidemia, P<0.0001) The incidence of RVO was associated with an increased risk of dementia development, (incidence rate ratio (IRR) : 1.183 in Alzheimer's disease, 1.491 in vascular dementia and 1.22 in total disease) even after adjusting for confounding factors. (age, sex, BMI, presence of diabetes, dyslipidemia)
결론 : Retinal vascular occlusion was significantly associated with vascular dementia development after adjusting for potential confounders.
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