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목적 : Ocular adnexal mucosa-associated lymphoid tissue lymphoma (OAML) is usually known as most common primary orbital malignancy. While radiotherapy is a treatment of choice for limited stage tumor, chemotherapy is required in disseminated diseases or those who cannot sustain radiotherapy. In this study, the authors examined the characteristics of OAML and treatment response after first-line chemotherapy.
방법 : Eighty patients with histopathologically confirmed OAML were treated with combination of cyclophosphamide, vincristine, and prednisolone (CVP) and selectively additional Rituximab (R-CVP) or combination of cyclophosphamide, hydroxydaunorubicin, oncovine and prednisolone (CHOP). Radiation therapy or additional chemotherapy with different regimen was undertaken for the chemotherapy failure cases.
결과 : Overall response rate of 100% was achieved in all patients regardless of different chemotherapy regimen; Complete remission (CR), 93.5% with R-CVP; 66.7% with CHOP; and 72.7% with CVP. After a median follow-up of 54 months, relapse occurred in 5 (6.2%) patients and was given radiation therapy in three patients and additional chemotherapy in the other two patients. The final response was CR in all patients except one patient who was lost to follow-up.
결론 : First-line chemotherapy is effective and well tolerated in patients with localized OAML (stage 1) and advanced stages (≥ stage 2). R-CVP therapy can achieve higher treatment response and higher progression-free survival (PFS).
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