| 발표일자: |
2018년 11월 2일(금) ~ 11월 4(일) |
| 발표번호: |
P(e-poster)-003 |
| 발표장소: |
코엑스 컨퍼런스룸 3층 301 A-B |
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| 안압이 조절되는 개방우각 녹내장에서 시신경섬유층 감소의 위험인자에 대한 연구 |
| 연세대학교 의과대학 안과학교실, 시기능개발연구소 |
| 이지혜, 배형원, 이상엽, 김찬윤, 성공제 |
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목적 : The purpose of this study was to identify risk factors associated with progressive retinal nerve fiber layer(RNFL) thinning of open-angle glaucoma(OAG) in patients whose intraocular pressure(IOP) was maintained low with medical treatment.
방법 : OAG patients with ≥ 60 months of follow-up and mean IOP below 15mmHg were recruited. All eyes underwent IOP measurement with Goldmann applantation tonometer(GAT), standard automated perimetry(SAP), and cirrus optical coherence tomography(cirrus OCT) at 6 month or 1 year intervals. RNFL thinning was assessed using the Guided Progression Analysis(GPA) software.
결과 : Fifty-six eyes of 56 patients were followed up for 79.2±7.1months. GPA detected 23 eyes(41.1%) with progressive RNFL thinning(-1.0±0.9um/year vs. -0.3±0.5um/year, P<0.001). Mean IOP after initiating therapy was 13.5±1.2mmHg in the progression group and 13.1±1.2mmHg in the non-progression group (P=0.299). Disc hemorrhage was found to more frequently occur in the progression group (P=0.001). Multivariate logistic regression analysis showed that patients with disc hemorrhage were at a higher risk for progressive RNFL thinning in OAG (OR 14.008; CI 1.355-144.865; P=0.027).
결론 : Disc hemorrhage is associated with progressive RNFL thinning in OAG with well-maintained IOP. Factors other than IOP appear to also play a role in OAG progression.
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