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목적 : To investigate the association between fundus findings and coronary artery calcium score (CACS).
방법 : The study included 1493 patients who registered in Cardiovascular and Metabolic Disease Etiology Research Center – High Risk Cohort (CMERC-HI, NCT02003781). All subjects measured CACS and took fundus images. Fundus was imaged by fundus photography and spectral-domain optical coherence tomography (OCT) for the detection of localized retinal nerve fiber layer defects (RNFLDs) and the grading of diabetic retinopathy (DR).
결과 : In subjects without diabetes mellitus (DM), localized RNFLDs were significantly associated with high CACS (>300) (p=0.014; odds ratio, 1.853 ; 95% confidence interval, 1.134-3.028 ) after adjusting for age, sex, estimated glomerular filtration rate (eGFR), systolic blood pressure (SBP), body mass index (BMI), low-density lipoprotein (LDL)-cholesterol. In diabetic patients, DR grades were significantly associated with high CACS (p=0.001; odds ratio, 1.693; 95% confidence interval, 1.238-2.316) after adjusting for age, sex, eGFR, SBP, BMI, LDL-cholesterol, HbA1c.
결론 : Localized RNFLDs in non-diabetic subjects and DR grades in diabetic subjects were associated with high CACS. Assessment of fundus morphology may be valuable in assessing risk of CVD in hypertensive patients.
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