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Purpose : To report a rare case of orbital lymphoma.
Methods : Here we report a patient who developed sequentially MALT lymphoma in parotid gland, DLBCL of lymph nodes in various parts of the body, MALT lymphoma in bronchus, MALT lymphoma in trachea, MALT lymphoma in left thigh, DLBCL in left orbit and DLBCL in right popliteal fossa. For the multifocal sites involving orbit, parotid gland, trachea and bronchus of two different NHLs.
An 49 years old male was admitted to hospital in September 2015 after the left orbital tumor was found 6 months ago. Left orbital mass resection surgery was performed and two tumors were resected. The bigger one was 3*2.5*1.4cm in the inferior orbit which was adjacent to inferior rectus muscle, and the smaller one was 1.7*1.2*0.6cm in the superior orbit on the temporal side.Excisional biopsy of the orbital mass showed diffuse infiltration of large lymphoid cells, which were positive for CD20 and bcl-2, but not for CD30, CD10, bcl-6, Mum-1 and CyclinD1. Ki-67 labeling index was 30%~40%. A clonal amplification peak was demonstrated in gene rearrangements of IgH and Igκ. These findings suggested DLBCL.
Results : The patient is still alive for the long history of 10 years. The case is very rare in clinic.
Conclusion : Physicians should give attention to the development of another type of NHL for a long period of time after achieving complete remission of one type of NHL.
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